The Introduction of Sibutramine
Sibutramine ,China Food and Drug Administration October 30, 2010 halted production and sales in China, the United States and the EU before the fda stop for weight loss, the reason is that sibutramine led to cardiovascular disease incidence.
【efficacy indications 】 hydrochloric acid sibutramine is applicable to diet and exercise can't reduce and control weight control obesity treatment, including lose weight and maintain weight loss, treatment should be and low quantity of heat with diet and exercise. Recommended for the treatment of body mass index quartile 30 kg/m2 or 27 kg/m2 (have other risk factors such as high blood pressure, diabetes, dyslipidemia, etc.) of the morbidly obese.
【The chemical composition 】 this product main ingredients for hydrochloric acid sibutramine.
【 pharmacology 】 this product is a function of the central nervous obesity drug treatment. Mainly through its amine class (still amine and "amine class) metabolism product and produce effect, its main mechanism to control norepinephrine, serotonin and dopamine reuptake and enhance feed feeling, and for norepinephrine, serotonin and dopamine release no significant effect. Research also shows that the product and its amine class activity metabolism product no significant anticholinergic, antihistamine and single oxidase, the inhibition.
Contraindications for receiving monoamine oxidase inhibitor (MAOI) therapy. Taboo for the composition of the goods allergic patients. Contraindicated for patients with anorexia nervosa. Contraindications for receiving other central appetite inhibitor patients. The treatment of gum disease fat diet and exercise should be based. Organic fat (if there is no treatment for hypothyroidism) should be excluded from the scope should be using. In the treatment of goods should be checked blood pressure and pulse before and during treatment should be regularly monitored. For those who when using continuous blood pressure and pulse leap Ho reduction or discontinuation should be considered. For patients with a history of hypertension should be used sparingly, can not be controlled or poorly controlled blood pressure in hypertensive patients should be prohibited. Because this product may cause heart rate and / or blood pressure. Therefore, some can cause nerve endings release of 5 - HT in central weight-loss drugs and heart valve dysfunction related.
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