The Introduction of Camptothecin
Camptothecin is a plant from South China, Southwest acuminata distribution be extracted. 1976, China Yisheng synthetic chemists high success racemic camptothecin. Camptothecin on the gastrointestinal tract and head and neck cancer have better short-term effect, but the small number of patients with hematuria side effects. 10 – hydroxycamptothecin anticancer activity than camptothecin, for liver cancer and head and neck cancer also have significant effects, and fewer side effects.
Properties: light yellow needle crystal (methanol – acetonitrile), decomposition point: 264 ℃ ~ 267 ℃, [α] 25D 31.3. (Chloroform – methanol). Strong performance in the blue under ultraviolet light, fluorescence, and acid can not form a stable salt. Pharmacological effects: anti-tumor, immunosuppressive, anti-virus, anti-early pregnancy, changes in skin epidermal keratinization process.
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