What is terbinafine and how does it work (mechanism of action)?

Terbinafine is an antifungal agent that is taken by mouth or applied to the skin. Terbinafine acts by interfering with the ability of fungi to make chemicals called sterols that are an important part of the membrane that surrounds fungal cells and holds them together. This weakens the cell…

Febuxostat inhibitor background

Febuxostat is a nonpurine inhibitor of xanthine oxidase that shares no structural homology to allopurinol or to hypoxanthine. Therapy with febuxostat leads to lowering of serum uric acid levels within a few weeks, and chronic therapy has been shown to decrease uric acid levels into target…

Brinzolamide mechanism of action

Brinzolamide is a highly specific inhibitor of CA-II, which is the main CA isoenzyme involved in the secretion of aqueous humor. Inhibition of CA in the ciliary process of the eye slows the formation of bicarbonate, and reduces sodium and fluid transport. This results in a reduction in the…

What are the side effects of norfloxacin-oral?

Side effects of norfloxacin are nausea, stomach cramps, dizziness, headache, abdominal pain, diarrhea, abnormal heart beats, and photosensitivity (sun sensitivity).Norfloxacin as well as other antibiotics in the fluoroquinolone class of antibiotics, has been associated with tendinitis and…

Identification of mode of action of camptothecin

Preliminary works of Moore BG, Kessel D, Bosmann HB, Horwitz, SB and others have established that the synthesis of macromolecules such as RNA, DNA and protein are inhibited by camptothecin in tumor or dividing mammalian cells. The inhibition over DNA synthesis was transient when the drug i…

Camptothecin abstract

Camptothecin is one of the human success stories in the history of drug discovery from natural resources. In this mini-review, the painstaking efforts of eminent scientists of different disciplines to isolate and identify camptothecin as active anticancer compound from Camptotheca acuminat…

About cilostazol

Cilostazol is used to treat intermittent claudication. This is a cramping pain that develops in the lower leg when you walk and is due to poor circulation. Vasodilators like cilostazol increase the distance you can walk before the pain develops. Cilostazol works in two ways. It increases b…

Beta cell selectivity of streptozotocin

Streptozotocin is a nitrosourea analogue in which the N-methyl-N-nitrosourea (MNU) moiety is linked to the carbon-2 of a hexose. The toxic action of streptozotocin and chemically related alkylating compounds requires their uptake into the cells. Nitrosoureas are usually lipophilic and tiss…